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Molecular Cancer Biology, Oncology, Imperial College London
London, United Kingdom

PhD fellowship in cancer metastasis – Applications are invited for a PhD studentship to commence 1st October 2009 within the Molecular Cell Biology Section, Department of Oncology, Faculty of Medicine, Imperial College London (Hammersmith Hospital Campus).

Closing date: 26 July 2009

PhD fellowship in cancer metastasis

The Prostate Cancer Charity PhD studentship

Tumour microenvironment and Cancer Metastasis teams, Department of Oncology, Faculty of Medicine

Applications are invited for a PhD studentship to commence 1st October 2009 within the Molecular Cell Biology Section, Department of Oncology, Faculty of Medicine, Imperial College London (Hammersmith Hospital Campus).

Sphingosine kinase-1signalling during prostate cancer cell motility, invasion and metastasis

A major clinical complication in patients with advanced prostate cancer (PC) is metastasis to bone. The impact of this problem is evident from its occurrence in 30% of men newly diagnosed with PC and up to 75% of patients at some time during their illness. Prostatic bone lesions result in high levels of morbidity with symptoms that can include severe pain, bone fractures, spinal cord compression and eventual paralysis or death.

In this proposal we aim to elucidate the mechanism(s) that underlie sphingosine kinase 1 (SK1)-induced PC cell motility. The major techniques used are: cell migration and motility analysis (screening video microscopy in Dunn and Boyden chambers), cell invasion analysis (Matrigel), cell co-culture, confocal microscopy, western blotting, enzyme in vitro activity assays and qRT-PCR. Depending on the results of the in vitro studies we will continue to investigate the suitability of SK1 as a potential target for blocking PC metastasis using in vivo models.

The successful candidate would be a motivated person, who wants to start a PhD project, has some laboratory experience, is familiar with molecular biology techniques and highly proficient in English. Previous publications are desirable but not essential.

Valuing diversity and committed to equality of opportunity

To apply:

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Hong Kong PhD Fellowship Scheme – Knowledge Management – The Hong Kong Polytechnic University

Description:

Established in 2009 by the Hong Kong Research Grants Council (RGC), the Hong Kong PhD Fellowship Scheme aims at attracting the best and brightest students in the world to pursue their PhD programs in Hong Kong’s institutions.

Eligibility

Those who are seeking admission as new full time PhD students in UGC-funded institutions of Hong Kong, irrespective of their country of origin and ethnic background, should be eligible to apply. Applicants should demonstrate outstanding qualities of academic performance, research ability / potential, communication and interpersonal skills, and leadership abilities.

The Fellowship

The Fellowship provides a monthly stipend of HK$20,0001 and a conference travel allowance of HK$10,0001 per year for the awardees for a maximum period of three years. 135 PhD Fellowships will be awarded for the 2010/11 academic year2.

1US$1 = HK$7.8 (rate for reference only)

2Academic year in Hong Kong normally starts in September.

Review Panels

Applications, subject to their areas of studies, will be reviewed by two Selection Panels with experts in the broad areas, one for science, medicine, engineering and technology and another one for humanities, social science and business studies.

Selection Criteria

While the academic excellence is of prime consideration, the Review Panels will take into account, but is not limited to, the four yardsticks below for the selection of candidates:

1. Academic excellence;
2. Research ability and potential;
3. Communication, and interpersonal skills; and
4. Leadership abilities.

Application Process

The Scheme will call for application in early September 2009.

Each applicant may choose up to two programs in one or two institutions for PhD study when applying for the Hong Kong PhD Fellowship. Application should be made through the Online Application System (OAS) which will be available in early September 2009. The Hong Kong PhD Fellowship application is also regarded as a formal application for admission to the PhD program(s) offered by the institution(s) concerned. Applicants are therefore required to fully comply with the admission requirements of their selected institutions and programs except the application deadline, which should strictly follow the stipulated deadline for the Fellowship scheme. Admission requirements of individual institutions are as follows:
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